The activation of gene transcription is a multistepprocess that is triggered by factors that recognize transcriptionalenhancer sites in DNA. These factors work with co-activators todirect transcriptional initiation by the RNA polymerase IIapparatus. The protein encoded by this gene is a subunit of theCRSP (cofactor required for SP1 activation) complex, which, alongwith TFIID, is required for efficient activation by SP1. Thisprotein is also a component of other multisubunit complexes e.g.thyroid hormone receptor-(TR-) associated proteins which interactwith TR and facilitate TR function on DNA templates in conjunctionwith initiation factors and cofactors. This protein contains abipartite nuclear localization signal. This gene is known to escapechromosome X-inactivation.
Pathway
Developmental Biology; Fatty acid, triacylglycerol, and ketone body metabolism; Gene Expression; Generic Transcription Pathway; Metabolism; Metabolism of lipids and lipoproteins; PPARA Activates Gene Expression; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
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