Anti-MDM2 polyclonal antibody (DPABH-28560)

Rabbit anti-Mouse MDM2 (aa 177-198) polyclonal antibody for WB Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Mouse, Rat, Human
Immunogen
Synthetic peptide: HRKRRRSLSFDPSLGLCELRE, corresponding to amino acids 177-198 of Mouse MDM2
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/5000. Predicted molecular weight: 55 kDa. This product has been assayed by ELISA against 0.1μg of the immunizing peptide.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
MDM2; transformed mouse 3T3 cell double minute 2; Mdm-2; AA415488; 1700007J15Rik; E3 ubiquitin-protein ligase Mdm2
Entrez Gene ID
UniProt ID

Product Background


Pathway
AKT phosphorylates targets in the cytosol; Androgen Receptor Signaling Pathway; Bladder cancer; Cell Cycle

Citations


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References


Slack, A; Chen, ZW; et al. The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102:731-736(2005).
Chang, NS; et al. The non-ankyrin C terminus of I kappa B alpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. JOURNAL OF BIOLOGICAL CHEMISTRY 277:10323-10331(2002).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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