Rabbit Anti-Human MCM3AP (N-terminal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Fusion protein corresponding to residues near the N terminal of human minichromosome maintenance complex component 3 associated protein

Conjugate

Application Notes

IHC: 1:50-1:200

General Notes

This product (Catalog No. DPABH-06187) is a rabbit-derived IgG polyclonal antibody raised against human MCM3AP. It has been affinity purified by protein A. The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability.
DPABH-06187 is suitable for use in IHC (1:50–1:200) application.
DPABH-06187 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

GANP; SAC3; MAP80

Entrez Gene ID

UniProt ID