Anti-MAS1L monoclonal antibody, clone FQS22551(C)

Antibody Isotype

IgG

Clone

FQS22551(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues in Human MAS1L (UniProt P35410).

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IP: 1/100 - 1/500; Flow Cyt: 1/10 - 1/100;

Alternative Names

MAS1L; MAS1 oncogene-like; mas-related G-protein coupled receptor MRG; dJ994E9.2; MAS L; MRG; MAS-R; MAS1-like; mas-related G protein-coupled MRG; MAS-L; MGC119987;

Entrez Gene ID

UniProt ID

Antigen Description

Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at Ser-62 and Ser-67, respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Pathway

GPCRs, Class A Rhodopsin-like, organism-specific biosystem;