Anti-MARS monoclonal antibody, clone NBSTE21C5

Antibody Isotype

IgG1

Clone

NBSTE21C5

Species Reactivity

Human

Immunogen

Recombinant Human MARS

Conjugate

Alternative Names

MARS; methionyl-tRNA synthetase; methionine--tRNA ligase, cytoplasmic; methionine tRNA ligase 1; cytoplasmic; MetRS; cytosolic methionyl-tRNA synthetase; methionine tRNA ligase 1, cytoplasmic; MRS; METRS; MTRNS; FLJ35667;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.

Pathway

Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Cytosolic tRNA aminoacylation, organism-specific biosystem; Gene Expression, organism-specific biosystem; Selenocompound metabolism, organism-specific biosystem;