Anti-MAPK9 (aa 217-230) polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to amino acids 217-230 at internal region of human MAPK9. The sequence is ELVKGCVIFQGTDH

Conjugate

Application Notes

ELISA: 1:16000; WB: 0.03-0.1 μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

MAPK9; mitogen-activated protein kinase 9; JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA; MAPK 9; Jun kinase; MAP kinase 9; c-Jun kinase 2; c-Jun N-terminal kinase 2; stress-activated protein kinase 1a; stress-activa

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this genes mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Pathway

AGE/RAGE pathway; Activated TLR4 signalling; Adipocytokine signaling pathway; CD40/CD40L signaling