Anti-MAPK7 (aa 561-677) polyclonal antibody

Species Reactivity

Human

Immunogen

MAPK7 (AAH07404, 561 a.a. ~ 677 a.a) partial recombinant protein with GST tag. The sequence is PQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGV ADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP

Conjugate

Alternative Names

MAPK7; mitogen-activated protein kinase 7; BMK1; ERK4; ERK5; PRKM7; BMK-1; ERK-5; MAPK 7; BMK1 kinase; MAP kinase 7; big MAP kinase 1; extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

Pathway

Activated TLR4 signalling; Cellular Senescence; EGFR1 Signaling Pathway; ERKs are inactivated