Anti-MAPK7 monoclonal antibody, clone 6D8

Antibody Isotype

IgG1

Clone

6D8

Species Reactivity

Human

Immunogen

Recombinant full length protein, corresponding to amino acids 1-816 of Human ERK5, produced in HEK293T cells (NP_002740).

Conjugate

Application Notes

WB: 1/2000; ICC/IF: 1/100;

Alternative Names

MAPK7; mitogen-activated protein kinase 7; PRKM7; BMK1; BMK1 kinase; ERK5; extracellular signal regulated kinase 5; BMK-1; ERK-5; MAPK 7; MAP kinase 7; big MAP kinase 1; extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5; ERK

Entrez Gene ID

UniProt ID

Antigen Description

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways.

Pathway

Activated TLR4 signalling, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; ERK/MAPK targets, organism-specific biosystem; ERKs are inactivated, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; Gap junction, organism-specific biosystem.