Anti-MAP3K11 (aa 741-847) polyclonal antibody

Species Reactivity

Human

Immunogen

MAP3K11 (NP_002410, 741 a.a. ~ 847 a.a) partial recombinant protein with GST tag. The sequence is PPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRR APWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP

Conjugate

Alternative Names

MAP3K11; mitogen-activated protein kinase kinase kinase 11; MLK3; PTK1; SPRK; MLK-3; MEKK11; mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; src-homology 3 domain-containing proline-rich kinase;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

Pathway

CDC42 signaling events; Insulin Signaling; MAPK signaling pathway; Non-alcoholic fatty liver disease (NAFLD)