Specifications
Species Reactivity
Mouse; Human
Immunogen
Synthetic peptide corresponding to residues on the C-terminus of human MLK3.
Applications
Application Notes
Flow Cyt: 1/15; WB: 1/5000; ICC/IF: 1/100 - 1/250.
Target
Alternative Names
MAP3K11; mitogen-activated protein kinase kinase kinase 11; MLK3, PTK1; MEKK11; SPRK; mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; src-homology 3 domain-containing proline-rich kinase; MLK3; PTK1; MLK-3;
Product Background
Antigen Description
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Pathway
CDC42 signaling events, organism-specific biosystem; IFN-gamma pathway, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; RAC1 signaling pathway, organism-specific biosystem.
Citations
Publication ()
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COA
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