This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neuritogenesis. MAP2 serves to stabilize microtubules (MT) growth by crosslinking MT with intermediate filaments and other MT. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described.
Pathway
Alzheimer's disease; Alzheimers Disease; Binding and Uptake of Ligands by Scavenger Receptors; Disease; Diseases associated with visual transduction; Malaria; PDGFR-beta signaling pathway; Retinoid metabolism and transport; Scavenging of Heme from Plasma; Signal Transduction; Statin Pathway; Visual phototransduction; Wnt Signaling Pathway NetPath; amb2 Integrin signaling
Citations
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