Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
Pathway
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; C-MYB transcription factor network; Cell Cycle Checkpoints; Cell cycle
Citations
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