Specifications
Immunogen
Recombinant fragment within Human MAD1 aa 50-200. The exact sequence is proprietary.Database link: Q9Y6D9
Applications
Application Notes
WB: 1/10000 - 1/50000; IHC-P: 1/50;
Target
Alternative Names
MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast); MAD1 (mitotic arrest deficient, yeast, homolog) like 1; mitotic spindle assembly checkpoint protein MAD1; HsMAD1; MAD1; PIG9; TP53I9; TXBP181; MAD1-like protein 1; tax-binding protein 181; tumor protei
Product Background
Antigen Description
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
Pathway
Amplificationof signal from unattachedkinetochores via a MAD2inhibitory signal, organism-specific biosystem; Amplification of signal from the kinetochores, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem;
Citations
Publication ()
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COA
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