Anti-LTA4H monoclonal antibody (DCABH-633)

Mouse anti-Human LTA4H monoclonal antibody for WB, IHC-P Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
0D6
Species Reactivity
Human
Immunogen
Protein expressed in 293T cell transfected with Human Leukotriene A4 hydrolase expression vector, (NM_000895).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; IHC-P: 1/50;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
LTA4H; leukotriene A4 hydrolase; leukotriene A-4 hydrolase; LTA-4 hydrolase; FLJ17564
Entrez Gene ID
UniProt ID

Product Background


Gene summary
LTA4H (Leukotriene A4 Hydrolase) is a Protein Coding gene. Among its related pathways are Metabolism and Arachidonic acid metabolism. GO annotations related to this gene include poly(A) RNA binding and peptidase activity. An important paralog of this gene is C9orf3. The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). The enzyme also has some peptidase activity. Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. The function about LTA4H antigen include aminopeptidase activity; binding; epoxide hydrolase activity; epoxide hydrolase activity; leukotriene-A4 hydrolase activity; leukotriene-A4 hydrolase activity; metal ion binding; metallopeptidase activity; peptidase activity; zinc ion binding.
Pathway
Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Eicosanoid Synthesis, organism-specific biosystem; Leukotriene synthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem.

Citations


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References


Surmiak, M; Kaczor, M; et al. EXPRESSION PROFILE OF PROINFLAMMATORY GENES IN NEUTROPHIL-ENRICHED GRANULOCYTES STIMULATED WITH NATIVE ANTI-PR3 AUTOANTIBODIES. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 63:249-256(2012).
Boger, PC; Shutt, JD; et al. Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma. HISTOPATHOLOGY 61:509-517(2012).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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