Anti-LILRB2 monoclonal antibody (CAB-3785MH)

Mouse anti-LILRB2 monoclonal antibody for ELISA, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2E5
Species Reactivity
Human
Immunogen
LILRB2 (AAH36827, 22 a.a.~599 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Applications


Application Notes
WB: 1:500-1000
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
LILRB2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; leukocyte immunoglobulin-like receptor subfamily B member 2; CD85d; ILT4; LIR 2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
LILRB2 (Leukocyte Immunoglobulin Like Receptor B2) is a Protein Coding gene. Among its related pathways are Immune System and Osteoclast differentiation. GO annotations related to this gene include receptor activity and protein phosphatase 1 binding. An important paralog of this gene is KIR2DL4. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. 4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. 4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene. 0The function about LILRB2 antigen include MHC class I protein binding; MHC class I protein binding; MHC class Ib protein binding; cell adhesion molecule binding; eukaryotic cell surface binding; inhibitory MHC class I receptor activity; inhibitory MHC class I receptor activity; protein binding; protein phosphatase 1 binding; receptor activity.
Pathway
Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem.

Citations


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References


Deng, M; Lu, ZG; et al. A motif in LILRB2 critical for Angptl2 binding and activation. BLOOD 124:924-935(2014).
Hunt, JS; Clavellina, CVZ; et al. Investigation of an antibody reported to identify leukocyte immunoglobulin-like receptors (LILRB2) on placental vascular smooth muscle. PLACENTA 31:249-250(2010).

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