Anti-LDLRAP1 monoclonal antibody, clone FQS24227

Antibody Isotype

IgG

Clone

FQS24227

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human ARH aa 250 to the C-terminus (Cysteine residue). The exact sequence is proprietary.Database link: Q5SW96

Conjugate

Application Notes

WB: 1/10000 - 1/50000;

Alternative Names

LDLRAP1; low density lipoprotein receptor adaptor protein 1; low density lipoprotein receptor adapter protein 1; ARH; ARH2; DKFZp586D0624; FHCB1; FHCB2; MGC34705; LDL receptor adaptor protein; autosomal recessive hypercholesterolemia protein; ARH1;

Entrez Gene ID

UniProt ID

Antigen Description

Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.

Pathway

Chylomicron-mediated lipid transport, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; LDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem;