Rabbit anti-Human Kidins220 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 1517-1547 of Human Kidins220 (Accessions: Q9ULH0, NP_065789.1)

Conjugate

Alternative Names

KIDINS220; kinase D-interacting substrate, 220kDa; kinase D-interacting substrate of 220 kDa; ankyrin repeat rich membrane spanning protein; ARMS; ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane-spanning protein; MGC163482;

Entrez Gene ID

UniProt ID

Antigen Description

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Pathway

ARMS-mediated activation; NGF signalling via TRKA from the plasma membrane; Neurotrophin signaling pathway; Prolonged ERK activation events; Signal Transduction; Signalling by NGF;