Anti-KIDINS220 monoclonal antibody, clone 4-C7

Antibody Isotype

IgG1

Clone

4-C7

Species Reactivity

Mouse

Immunogen

Recombinant protein of Mouse Kidins220.

Conjugate

Application Notes

WB: 1/500 - 1/1000; ICC: 1/100 - 1/500;

Alternative Names

KIDINS220; kinase D-interacting substrate 220; kinase D-interacting substrate of 220 kDa; AI194387; AI316525; mKIAA1250; 3110039L19Rik; C330002I19Rik;

Entrez Gene ID

UniProt ID

Antigen Description

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Pathway

ARMS-mediated activation, organism-specific biosystem; NGF signalling via TRKA from the plasma membrane, organism-specific biosystem; Neurotrophin signaling pathway, organism-specific biosystem; Neurotrophin signaling pathway, conserved biosystem; Prolonged ERK activation events, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signalling by NGF, organism-specific biosystem;