Anti-KIF5B monoclonal antibody, clone FQS21387(C)

Antibody Isotype

IgG

Clone

FQS21387(C)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide, corresponding to residues in Human KIF5B (Uniprot: P33176).

Conjugate

Application Notes

WB: 1/1000 - 1/10000; IHC-P: 1/100 - 1/250; ICC/IF: 1/100 - 1/250; IP: 1/10 - 1/100.

Alternative Names

KIF5B; kinesin family member 5B; KNS1; kinesin-1 heavy chain; KNS; kinesin heavy chain; kinesin 1 (110-120kD); ubiquitous kinesin heavy chain; conventional kinesin heavy chain; KINH; UKHC;

Entrez Gene ID

UniProt ID

Antigen Description

KIF5B is a kinesin. These are microtubule based motor proteins involved in the transport of organelles in eukaryotic cells. They typically consist of 2 identical, approximately 110 to 120 kD heavy chains and 2 identical, approximately 60 to 70 kD light chains. The heavy chain contains 3 domains: a globular N terminal motor domain, which converts the chemical energy of ATP into a motile force along microtubules in 1 fixed direction; a central alpha helical rod domain, which enables the 2 heavy chains to dimerize; and a globular C terminal domain, which interacts with light chains and possibly an organelle receptor.

Pathway

Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem; Insulin Signaling, organism-specific biosystem;