Anti-KIF5B monoclonal antibody, clone TVL-5

Antibody Isotype

IgG1

Clone

TVL-5

Species Reactivity

Sea urchin

Immunogen

Full length native protein (purified): 130kD heavy chain of sea urchin kinesin.

Conjugate

Application Notes

WB: 1/1000. Predicted molecular weight: 120 kDa. ICC/IF: 1/500 - 1/1000. PubMed: 19743964

Alternative Names

KIF5B; kinesin family member 5B; kinesin-1 heavy chain; UKHC; ubiquitous kinesin heavy chain; conventional kinesin heavy chain; Khc;

Entrez Gene ID

UniProt ID

Antigen Description

Kinesin is a microtubule associated force producing protein that may play a role in organelle transport. It is an oligomer composed of two heavy chains and two light chains. It interacts with GRIP1. It is composed of three structural domains: a large globular N terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles. Found in newborn and adult brain, liver, kidney, spleen, heart, lung and sciatic nerve.

Pathway

Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; Insulin Signaling, organism-specific biosystem; Insulin Synthesis and Processing, organism-specific biosystem;