Anti-KCNMB4 monoclonal antibody, clone T29B-4

Antibody Isotype

IgG2a

Clone

T29B-4

Species Reactivity

Mouse; Rat; Human

Immunogen

Fusion protein, corresponding to extracellular amino acids 45 - 167 of Mouse KCNMB4 (NP_067427).

Conjugate

Application Notes

WB: 1 μg/ml; IHC-P: 0.1 - 1 μg/ml; IHC-Fr: 0.1 - 1 μg/ml; ICC: 0.1 - 1 μg/ml; ICC/IF: 1 - 10 μg/ml;

Alternative Names

KCNMB4; potassium large conductance calcium-activated channel, subfamily M, beta member 4; calcium-activated potassium channel subunit beta-4; BKbeta4; slo-beta-4; k(VCA)beta-4; Slowpoke beta 4; BK channel subunit beta-4; maxi K channel subunit beta-4; ch

Entrez Gene ID

UniProt ID

Antigen Description

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.

Pathway

Hemostasis, organism-specific biosystem; Nitric oxide stimulates guanylate cyclase, organism-specific biosystem; Platelet homeostasis, organism-specific biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem; cGMP effects, organism-specific biosystem;