Anti-KCNJ3 monoclonal antibody, clone FQS7474

Antibody Isotype

IgG

Clone

FQS7474

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide corresponding to residues in the extracellular domain of Human GIRK1. (Uniprot: P48549)

Conjugate

Application Notes

WB: 1/1000 - 1/10000; Flow Cyt: 1/100 - 1/500.

Alternative Names

KCNJ3; potassium inwardly-rectifying channel, subfamily J, member 3; G protein-activated inward rectifier potassium channel 1; GIRK1; KGA; Kir3.1; GIRK-1; inward rectifier K+ channel KIR3.1; inward rectifier K(+) channel Kir3.1; potassium channel, inwardl

Entrez Gene ID

UniProt ID

Antigen Description

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.

Pathway

Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; G Protein Signaling Pathways, organism-specific biosystem;