Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Serratrice, G; Pellisser, JF; et al. Potassium channelopathies and Morvan's syndromes. BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE 194:391-406(2010).
Nusing, RM; Pantalone, F; et al. Expression of the potassium channel ROMK in adult and fetal human kidney. HISTOCHEMISTRY AND CELL BIOLOGY 123:553-559(2005).
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