Anti-IL2RG monoclonal antibody, clone SN1473-7B32

Antibody Isotype

IgG2

Clone

SN1473-7B32

Species Reactivity

Mouse

Immunogen

Recombinant Mouse soluble IL2 Receptor gamma.

Conjugate

Application Notes

Flow Cyt: 1/10 - 1/50.

Alternative Names

IL2RG; interleukin 2 receptor, gamma chain; cytokine receptor common subunit gamma; p64; IL-2RG; gammaC; gamma C receptor; common gamma chain; IL-2R subunit gamma; IL-2 receptor subunit gamma; common cytokine receptor gamma chain; interleukin-2 receptor s

Entrez Gene ID

UniProt ID

Antigen Description

A common subunit for the receptors for a variety of interleukins, the gamma chain is common to the IL2, IL4, IL7, IL21 and probably also the IL13 receptors. Defects in IL2RG are the cause of X-linked severe combined immunodeficiency. The biological effects of IL2R signals are much more complex than simply mediating T-cell growth. Depending on conditions, IL2R signals may also promote cell survival, effector function, and apoptosis. These sometimes contradictory effects underscore the fact that a diversity of intracellular signalling pathways are potentially activated by IL2R. There are at least 3 components of the IL2 receptor; IL2R alpha, IL2R beta, and IL2R gamma chains.

Pathway

Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;