General Notes
This product (Catalog No. DPABH-04519) is a rabbit-derived polyclonal antibody raised against human ITGB1, targeting the amino acid region 86–461 of the protein. This antibody exhibits cross-reactivity with Human ITGB1 from mouse and rat. It has been affinity purified by Protein A. Integrin beta 1 (ITGB1), also known as CD29, is the most abundant and widely expressed beta subunit of the integrin family of transmembrane heterodimeric adhesion receptors, which mediate critical interactions between cells and the extracellular matrix (ECM) as well as cell-cell contacts. Encoded by the ITGB1 gene on human chromosome 10p11.22, it forms functional complexes with at least 12 different alpha subunits (such as α1, α2, α3, α4, α5, α6, α7, α8, α9, α10, α11, and αV), enabling recognition of diverse ECM ligands including fibronectin, collagen types I-VI, laminin, and vitronectin. These interactions trigger bidirectional signaling—inside-out activation for ligand binding and outside-in signaling for intracellular responses—essential for fundamental biological processes.
DPABH-04519 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-04519 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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