Anti-ITGB1; ITGA3 monoclonal antibody, clone Q2C6

Antibody Isotype

IgG1

Clone

Q2C6

Species Reactivity

Human

Immunogen

Human HT1080 cells.

Conjugate

Application Notes

IP: 1/1000; IHC-Fr: 1/100.

Alternative Names

ITGA3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); antigen identified by monoclonal J143 , MSK18; integrin alpha-3; CD49c; GAP B3; VCA 2; VLA3a; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C;

Entrez Gene ID

UniProt ID

Antigen Description

Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha IIB/beta 3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha IIB/beta 3 and alpha V/beta 3 recognise the sequence R G D in a wide array of ligands. Integrin alpha IIB/beta 3 recognises the sequence H H L G G G A K Q A G D V in fibrinogen gamma chain. Following activation integrin alpha IIB/beta 3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.

Pathway

Arf6 trafficking events, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Basigin interactions, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem.