Specifications
Immunogen
Rat oesophageal carcinoma cell line B2T
Applications
Application Notes
Flow Cyt: Neat
Target
Alternative Names
ITGA6; integrin, alpha 6; integrin alpha-6
Product Background
Antigen Description
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Citations
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Mellerio, JE; Pulkkinen, L; et al. Pyloric atresia-junctional epidermolysis bullosa syndrome: mutations in the integrin beta 4 gene (ITGB4) in two unrelated patients with mild disease. BRITISH JOURNAL OF DERMATOLOGY 139:862-871(1998).
Fukushima, K; Miyamoto, S; et al. Tumor necrosis factor and vascular endothelial growth factor induce endothelial integrin repertories, regulating endovascular differentiation and apoptosis in a human extravillous trophoblast cell line. BIOLOGY OF REPRODUCTION 73:172-179(2005).
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