IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]
Pathway
Activated TLR4 signalling; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Apoptosis; Cytokine Signaling in Immune system; Cytosolic DNA-sensing pathway; Cytosolic sensors of pathogen-associated DNA; DEx/H-box helicases activate type I IFN and inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production.
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