INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Chen, JD; Ezzeddine, N; et al. An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3 '-end formation. RNA-A PUBLICATION OF THE RNA SOCIETY 18:2148-2156(2012).
Egloff, S; Szczepaniak, SA; et al. The Integrator Complex Recognizes a New Double Mark on the RNA Polymerase II Carboxyl-terminal Domain. JOURNAL OF BIOLOGICAL CHEMISTRY 285:20564-20569(2010).
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