Specifications
Immunogen
IKK gamma antibody was raised against a peptide corresponding to amino acids 400 to 416 of human IKK gamma, which are identical to those of mouse homologue.
Target
Alternative Names
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; AMCBX1; ZC2HC9; IKK-gamma; NF-kappa-B essential modulator; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ik
Product Background
Antigen Description
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]
Pathway
Activated TLR4 signalling; Activation of NF-kappaB in B cells; Acute myeloid leukemia; Adaptive Immune System; Adipocytokine signaling pathway; Apoptosis; B Cell Receptor Signaling Pathway; B cell receptor signaling pathway
Citations
Publication ()
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COA
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