Anti-IGKC monoclonal antibody, clone IQ7064

Antibody Isotype

IgG1

Clone

IQ7064

Species Reactivity

Human

Immunogen

Purified human IGKC.

Conjugate

Application Notes

Flow Cytometry (0.5-2 ug/million cells); Immunohistochemistry (0.5-1 μg/mL for 30 min at RT); Immunoprecipitation (1-2 ug/500 ug protein lysate); WB (0.5-1 μg/mL) & The optimal working dilution should be determined by the end user.

Alternative Names

IGKC; Immunoglobulin kappa constant;

Entrez Gene ID

Antigen Description

Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pen tamer. IgA may also form polymers. Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83.