Anti-IGFBP3 polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to human IGFBP3. The sequence is C-RYKVDYESQSTDTQN

Conjugate

Application Notes

ELISA: 1:64000; WB: 0.02-0.06 μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

IGFBP3; insulin-like growth factor binding protein 3; IBP3; BP-53; insulin-like growth factor-binding protein 3; IBP-3; IGFBP-3; binding protein 29; binding protein 53; IGF-binding protein 3; growth hormone-dependent binding protein; acid stable subunit o

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Pathway

Direct p53 effectors; Metabolism of proteins; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Transcriptional misregulation in cancer