Anti-IGFBP3 polyclonal antibody [Biotin]

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Mouse myeloma cell line NS0-derived recombinant human IGFBP-3 . Gly28-Lys291 Accession Number CAA46087

Conjugate

Application Notes

Western Blot: 0.1 μg/mL; ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4042 - DPABY-445

Alternative Names

IGFBP3; insulin-like growth factor binding protein 3; IBP3; BP-53; insulin-like growth factor-binding protein 3; IBP-3; IGFBP-3; binding protein 29; binding protein 53; IGF-binding protein 3; growth hormone-dependent binding protein; acid stable subunit o

Entrez Gene ID

UniProt ID

Antigen Description

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

Pathway

Direct p53 effectors; Integrated Pancreatic Cancer Pathway; Metabolism of proteins; Myometrial Relaxation and Contraction Pathways; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)