Anti-IFIH1 monoclonal antibody, clone FQS7854 Knockout Validated

Antibody Isotype

IgG

Clone

FQS7854

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within Human MDA5. (Q9BYX4)

Conjugate

Application Notes

WB: 1/1000 - 1/10000; ICC/IF: 1/250 - 1/500.

Alternative Names

IFIH1; interferon induced with helicase C domain 1; interferon-induced helicase C domain-containing protein 1; helicard; Hlcd; IDDM19; MDA 5; MDA5; CADM-140 autoantigen; helicase with 2 CARD domains; RNA helicase-DEAD box protein 116; murabutide down-regu

Entrez Gene ID

UniProt ID

Antigen Description

RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential for the production of interferons in response to picornaviruses.

Pathway

Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; Immune System, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem; Innate Immune System, organism-specific biosystem; Measles, organism-specific biosystem;