Anti-IFIH1 (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

MDA5 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human MDA5.

Conjugate

Alternative Names

IFIH1; interferon induced with helicase C domain 1; AGS7; Hlcd; MDA5; MDA-5; RLR-2; IDDM19; interferon-induced helicase C domain-containing protein 1; helicard; CADM-140 autoantigen; RIG-I-like receptor 2; helicase with 2 CARD domains; RNA helicase-DEAD b

Entrez Gene ID

UniProt ID

Antigen Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]

Pathway

Hepatitis B; Herpes simplex infection; Immune System; Influenza A; Innate Immune System; Measles; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of RIG-I/MDA5 signaling