Anti-TXN monoclonal antibody, clone 4B2

Antibody Isotype

IgG2b, κ

Clone

4B2

Species Reactivity

Human

Immunogen

Recombinant full length protein (Human) purified from E.coli

Conjugate

Application Notes

Flow Cyt: 1μg/10⁶ cells; WB: 1/2000.

Alternative Names

TXN; thioredoxin; TRX; ADF; Surface associated sulphydryl protein; TXN protein; ATL derived factor; ATL-derived factor; DKFZp686B1993; MGC61975; SASP; Surface-associated sulphydryl protein; THIO_HUMAN; Thioredoxin; TRDX; TRX 1; Trx; TRX1; TXN; ADF; SASP;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Pathway

Folic Acid Network, organism-specific biosystem; Folic Acid Network, organism-specific biosystem; Immune System, organism-specific biosystem; Inflammasomes, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem; Selenium Pathway, organism-specific biosyste