Anti-ST6GALNAC1 polyclonal antibody (CPBT-57881RH)

Rabbit anti-Human ST6GALNAC1 (aa 396-445) polyclonal antibody for ICC/IF, WB, ELISA

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to a region within internal sequence amino acids 396-445 (LIKGYEQDVG TRTSFYGFTA FSLTQSLLIL GNRGFKNVPL GKDVRYLHFL) of human ST6GALNAC1.
Conjugate
Unconjugated

Applications


Application Notes
ICC/IF: 1 μg/ml; WB: 1 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
ST6GALNAC1; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; sialyltransferase 7 ((alpha N acetylneuraminyl 2,3 beta galactosyl 1,3) N acetyl galactosaminide alpha 2,6 sialyltransferase) A , SI
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ST6GALNAC1 (ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include sialyltransferase activity and alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. An important paralog of this gene is ST3GAL4. Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al. , 1999 [PubMed 10536037]; Sewell et al. , 2006 [PubMed 16319059]).
Antigen Description
Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al. , 1999Protein Symbol:Q9NSC7-SIA7A_HUMANRecommended name:Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1Protein Accession:Q9NSC7Secondary Accessions:Q6UW90Q9NSC6Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene. 0The function about ST6GALNAC1 antigen include alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity; sialyltransferase activity.
Pathway
Metabolic pathways, organism-specific biosystem; Mucin type O-Glycan biosynthesis, organism-specific biosystem; Mucin type O-Glycan biosynthesis, conserved biosystem.

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References


Kato, T; Iwamoto, K; et al. Comprehensive DNA methylation and hydroxymethylation analysis in the human brain and its implication in mental disorders. NEUROPHARMACOLOGY 80:133-139(2014).

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