General Notes
This product (Catalog No. DPABH-08814) is a rabbit-derived polyclonal antibody raised against human ST6GALNAC1. It has been affinity purified by Protein A. ST6GALNAC1 is a gene that encodes an enzyme known as α-N-acetylgalactosaminide α-2,6-sialyltransferase 1 (ST6GalNAc-I), which catalyzes the transfer of sialic acid (N-acetylneuraminic acid, Neu5Ac) in an α-2,6 linkage to the O-linked N-acetylgalactosamine (GalNAc) residues on glycoproteins, thereby forming the sialyl-Tn (STn) antigen. This sialyltransferase is predominantly expressed in goblet cells of the intestinal epithelium and plays a critical role in regulating protein glycosylation, which influences cell-cell interactions, extracellular matrix adhesion, and intracellular signaling pathways. In physiological contexts, ST6GalNAc-I contributes to intestinal host-commensal homeostasis by modulating mucin glycosylation, thereby supporting barrier function and microbial interactions in the gut. (PubMed:35303419) Dysregulation of ST6GALNAC1 expression is implicated in oncogenesis, where elevated STn antigen levels serve as a tumor-associated marker in cancers such as breast, gastric, and colorectal, promoting invasion, metastasis, and stem cell-like properties through mechanisms including STAT5b-mediated IGF-1 gene regulation and activation of intracellular signaling. The gene is located on human chromosome 17q25.1 and consists of 12 exons, with its product exhibiting tissue-specific expression primarily in mucus-secreting cells.
DPABH-08814 is suitable for use in IHC 1 (50-1:200) application.
DPABH-08814 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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