Specifications
Immunogen
Recombinant full length protein, corresponding to amino acids 24-149 of Human RAMP3
Applications
Application Notes
WB: 1-5 μg/ml.
Target
Alternative Names
RAMP3; receptor (G protein-coupled) activity modifying protein 3; receptor (calcitonin) activity modifying protein 3 ,receptor activity modifying protein 3; receptor activity-modifying protein 3; Calcitonin receptor like receptor activity modifying protei
Product Background
Antigen Description
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
Pathway
Calcitonin-like ligand receptors, organism-specific biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem; Vascular smooth muscle contr
Citations
Publication ()
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COA
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