Anti-HNF4A monoclonal antibody, clone FQS5052

Antibody Isotype

IgG2a

Clone

FQS5052

Species Reactivity

Mouse; Rat; Cow; Human

Immunogen

Baculovirus-expressed recombinant fragment: MADYSAALDP AYTTLEFENV QVLTMGNDTS PSEGTNLNAP NSLGVSAL, corresponding to amino acids 3-49 of Human HNF4

Conjugate

Application Notes

WB: 1μg/ml; ELISA: 0.1μg/mlIHC-P: 10 - 20μg/ml; ICC/IF: 1μg/ml; Flow Cyt: 1-2μg/10⁶ cells;

Alternative Names

HNF4A; hepatocyte nuclear factor 4, alpha; TCF; HNF4; MODY; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.

Pathway

Developmental Biology, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem; Maturity onset diabetes of the young, conserved biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem;