Anti-HLA-DQB1 monoclonal antibody, clone Hfopy 4.64

Name: Anti-HLA-DQB1 monoclonal antibody, clone Hfopy 4.64
SKU: CABT-34183MH
Rating: 5 (1 reviews)

Mouse anti-Human HLA-DQB1 monoclonal antibody for ELISA, FC, IHC-Fr

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG1

Clone

Hfopy 4.64

Species Reactivity

Human

Immunogen

Tissue / cell preparation (Human).Bristol 8 glycoprotein from the Bristol 8 B lymphoblastoid cell line.

Conjugate

Unconjugated

Target

Alternative Names

HLA-DQB1; major histocompatibility complex, class II, DQ beta 1; HLA DQB; HLA class II histocompatibility antigen, DQ beta 1 chain; CELIAC1; IDDM1; CELIAC1; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA DQB; HLA DQB1; IDDM1; Lymphocyte ant

Entrez Gene ID

3119

UniProt ID

Q5SU54

Product Background

Antigen Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Pathway

Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

HLA-DQB1*06:132, an HLA-DQB1*06 variant, discovered in a Singaporean Malay bone marrow donor

HLA

Authors: Cho, Louise; Kaur, Ashminder; Cereb, Nezih; Lin, Py-Yu; Yang, Kuo-Liang

Abstract

One nucleotide substitution in codon 38 of HLA-DQB1*06:01:01:01 results in a novel allele, HLA-DQB1*06:132.

HLA Class II Genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 Are Associated With the Antibody Response to Inactivated Japanese Encephalitis Vaccine

FRONTIERS IN IMMUNOLOGY

Authors: Yao, Yufeng; Yang, Huijuan; Shi, Lei; Liu, Shuyuan; Li, Chuanying; Chen, Jun; Zhou, Ziyun; Sun, Mingbo; Shi, Li

Abstract

Aim: The objective of this study was to evaluate the association of the human leukocyte antigen (HLA) class II genes HLA-DRB1, HLA-DPB1, and HLA-DQB1 with the humoral immune response elicited by inactivated Japanese encephalitis (JE) vaccine (IJEV). Methods: A total of 373 individuals aged 3-12 years in the Inner Mongolia Autonomous Region in China, who received two doses of IJEV at 0 and 7 days, were enrolled in the current study. Based on the individuals' specific JE virus (JEV)-neutralizing antibodies (NAbs), they were divided into a seropositive and a seronegative group. HLA-DRB1, HLA-DPB1, and HLA-DQB1 were genotyped using a sequencing-based typing method. Next, the association of the HLA class II genes and their haplotypes with antibody response was evaluated. Results: Based on NAbs, a total of 161 individuals were classified as seropositive and 212 as seronegative. DQB1 *02:01 was significantly associated with JEV seropositivity (P < 0.001, OR = 0.364, 95% CI: 0.221-0.600), while DQB1 *02:02 was significantly associated with JEV seronegativity (P = 5.03 x 10(-6), OR = 7.341, 95% CI: 2.876-18.736). The haplotypes DRB1 *07:01-DPB1 *04:01-DQB1 *02:01, DRB1 *15:01-DPB1 *02:01-DQB1 *06:02, DRB1 *07:01-DQB1 *02:01, and DPB1 *02:01-DQB1 *06:02 were very frequent in the seropositive group, while DRB1 *07:01-DPB1 *17:01-DQB1 *02:02, DRB1 *07:01-DQB1 *02:02, and DPB1 *17:01-DQB1 *02:02 were very frequent in the seronegative group. The presence of DRB1 *01:01, DRB1 *04:05, DRB1 *09:01, DRB1 *12:02, DRB1 *13:02, and DRB1 *14:01 was associated with a higher geometric mean titer (GMT) of NAbs than that of DRB1 *11:01 at the DRB1 locus (P < 0.05). At the DPB1 locus, the presence of DPB1 *05:01 was associated with higher GMTs than that of DPB1 *02:01 and DPB1 *13:01 (P < 0.05), and the presence of DPB1 *04:01 and DPB1 *09:01 was associated with higher GMTs than that of DPB1 *13:01 (P < 0.05). Conclusions: The present study suggests that HLA class II genes may influence the antibody response to IJEV.