Anti-HLA-DQB1 (aa 1-189) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment within Human HLA DQB1 aa 1-189. The exact sequence is proprietary.Database link: P01920

Conjugate

Application Notes

WB: 1/500 - 1/3000; ICC/IF: 1/100 - 1/1000;

Alternative Names

HLA-DQB1; major histocompatibility complex, class II, DQ beta 1; IDDM1; CELIAC1; HLA-DQB; HLA class II histocompatibility antigen, DQ beta 1 chain; MHC DQ beta; MHC class2 antigen; lymphocyte antigen; MHC class II antigen DQB1; MHC class II DQ beta chain;

Entrez Gene ID

UniProt ID

Antigen Description

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

Pathway

Adaptive Immune System; Allograft rejection; Antigen processing and presentation; Asthma