Anti-FLI1 monoclonal antibody (DMAB5570MH)

Mouse anti-Human FLI1 monoclonal antibody for IHC Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG
Clone
CW5
Species Reactivity
Human
Immunogen
A synthetic cyclic peptide from the antigen’s c-terminus.
Conjugate
Unconjugated

Target


Alternative Names
FLI1; Friend leukemia virus integration 1; EWSR2; SIC-1; Friend leukemia integration 1 transcription factor; proto-oncogene Fli-1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
FLI1 (Fli-1 Proto-Oncogene, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with FLI1 include ewing sarcoma and isolated delta-storage pool disease. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is ETS2. This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Antigen Description
Friend leukemia integration 1 transcription factor (FLI1), also known as proto-oncogene Fli-1 or transcription factor ERGB, is a protein that in humans is encoded by the human FLI1 gene. Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1. Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene. Fli-1 is a member of the ETS transcription factor family that was first identified in erythroleukemias induced by Friend Murine Leukemia Virus (F-MuLV). Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias. The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation. The function about FLI1 antigen include DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity.
Pathway
Transcriptional misregulation in cancers.

Citations


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References


Lin, O; Filippa, DA; et al. Immunohistochemical Evaluation of FLI-1 in Acute Lymphoblastic Lymphoma (ALL) A Potential Diagnostic Pitfall. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 17:409-412(2009).
Scotlandi, K; Picci, P; et al. Targeted Therapies in Bone Sarcomas. CURRENT CANCER DRUG TARGETS 9:843-853(2009).

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