Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene. The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations.
Pathway
DNA Repair; Double-Strand Break Repair; Fanconi anemia pathway; Homologous DNA pairing and strand exchange; Homologous Recombination Repair; Homologous recombination repair of replication-independent double-strand breaks
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