Cyclin-dependent kinase-5(CDK5) is a member of the cyclin-dependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in the kidneys, testes, and ovaries. And Its activity has been detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity; however, Cdk5 is not activated by cyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits, called p35 and p39. These two activators regulate the spatial and temporal expression of active Cdk5, restricting its activity primarily to post-mitotic neurons.
Pathway
Alzheimer"s disease; Axon guidance; CRMPs in Sema3A signaling; DARPP-32 events; Developmental Biology; EPHA forward signaling; Factors involved in megakaryocyte development and platelet production; Glucocorticoid receptor regulatory network; Hemostasis; IL-6 Signaling Pathway; Lissencephaly gene (LIS1) in neuronal migration and development; Nicotine Activity on Dopaminergic Neurons; Opioid Signalling; Reelin signaling pathway; Semaphorin interactions
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