Anti-CLEC4E monoclonal antibody (CABT-30430MH)

Mouse anti-Human CLEC4E monoclonal antibody for ELISA, ICC/IF, IHC-P, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
BU27F4
Species Reactivity
Human
Immunogen
Recombinant fragment purified from E. coli, corresponding to amino acids 41-219 of Human CLEC4E
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/250 - 1/500; ICC/IF: 1/250 - 1/500; Flow Cyt: 1μg/106 cells.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CLEC4E; C-type lectin domain family 4, member E; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , CLECSF9; C-type lectin domain family 4 member E; mincle; C type lectin domain family 4 member E
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLEC4E (C-Type Lectin Domain Family 4 Member E) is a Protein Coding gene. Among its related pathways are Immune System and CLEC7A (Dectin-1) signaling. GO annotations related to this gene include receptor activity and carbohydrate binding. An important paralog of this gene is CLEC6A. This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
Antigen Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. The function about CLEC4E antigen include binding; receptor activity; sugar binding.
Pathway
Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem.

Citations


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References


Thiyagarajan, D; Fismen, S; et al. Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e. PLOS ONE 7:-(2012).
Keino, H; Watanabe, T; et al. Effect of Infliximab on Gene Expression Profiling in Behcet's Disease. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 52:7681-7686(2011).

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