Specifications
Antibody Isotype
IgG2b, κ
Immunogen
Recombinant fragment purified from E. coli, corresponding to amino acids 41-219 of Human CLEC4E
Applications
Application Notes
WB: 1/250 - 1/500; ICC/IF: 1/250 - 1/500; Flow Cyt: 1μg/106 cells.
Target
Alternative Names
CLEC4E; C-type lectin domain family 4, member E; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , CLECSF9; C-type lectin domain family 4 member E; mincle; C type lectin domain family 4 member E; C type lectin supe
Product Background
Antigen Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Pathway
Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem.
Citations
Publication ()
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COA
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