Anti-CLEC4E monoclonal antibody, clone 3B9

Antibody Isotype

IgG1

Clone

3B9

Species Reactivity

Human

Immunogen

Recombinant full length protein, corresponding to amino acids 1-219 of Human CLEC4E produced in HEK293T cells (NP_055173).

Conjugate

Application Notes

WB: 1/2000; IHC-P: 1/150; Flow Cyt: 1/100;

Alternative Names

CLEC4E; C-type lectin domain family 4, member E; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , CLECSF9; C-type lectin domain family 4 member E; mincle; C-type lectin superfamily member 9; macrophage-inducible C

Entrez Gene ID

UniProt ID

Antigen Description

C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

Pathway

Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem;