Anti-Human CD9 Antibody (CABT-33295MH)

Mouse anti-Human CD9 Monoclonal antibody [clone NFN-72] for FC, FuncS, IHC-P, IP, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
NFN-72
Species Reactivity
Human
Immunogen
Tissue / cell preparation (Human). (Pre-B line Nalm-6).
Conjugate
Unconjugated

Target


Alternative Names
CD9; CD9 molecule; CD9 antigen (p24) , MIC3; CD9 antigen; BA2; motility related protein 1
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
CD9 belongs to proteins of tetraspanin family that orchestrate cholesterol-associated tetraspanin-enriched signaling microdomains within the plasma membrane, forming complexes with each other as well as with integrins, membrane-anchored growth factors and other proteins. CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 is also considered as metastasis suppressor in solid tumors.
Pathway
Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem; Response to elevated platelet cytosolic Ca2+, organism-specific biosystem; a6b1 and a6b4 Integrin signaling, organism-specific biosystem;

Citations


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References


Nakamoto, T; Murayama, Y; et al. A novel therapeutic strategy with anti-CD9 antibody in gastric cancers. JOURNAL OF GASTROENTEROLOGY 44:889-896(2009).
Charrin, S; Le Naour, F; et al. The major CD9 and CD81 molecular partner - Identification and characterization of the complexes. JOURNAL OF BIOLOGICAL CHEMISTRY 276:14329-14337(2001).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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