Anti-CD8 monoclonal antibody (DMAB6659MH)

Mouse Anti-Human CD8 monoclonal antibody for ICC, IHC-Fr Datasheet

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Specifications


Host Species
Mouse
Clone
SJW12
Species Reactivity
Human
Conjugate
Unconjugated

Target


Alternative Names
CD8A; CD8a molecule; CD8; MAL; p32; Leu2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CD8A (CD8a Molecule) is a Protein Coding gene. Diseases associated with CD8A include cd8 deficiency, familial and susceptibility to respiratory infections associated with cd8alpha chain mutation. Among its related pathways are Immune System and Innate Lymphoid Cell Differentiation Pathways. GO annotations related to this gene include protein homodimerization activity and coreceptor activity. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
CD8 is a type I transmembrane glycoprotein expressed on a majority of thymocytes and also a subpopulation of peripheral blood T cells and NK cells. CD8 is a marker of cytotoxic T cells, which are specific for antigens presented by Major Histocompatibility Complex (MHC) class I molecules. CD8 deficiency, familial (CD8 deficiency) [MIM:608957]: An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. Note=The disease is caused by mutations affecting the gene represented in this entry. CD8a (Cluster of Differentiation 8a), is a human gene. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified. The function about CD8 antigen include MHC class I protein binding; coreceptor activity; protein binding; protein homodimerization activity; protein kinase binding.
Pathway
Adaptive Immune System; Antigen processing and presentation; Cell adhesion molecules (CAMs); Downstream signaling in naive CD8+ T cells; Hematopoietic cell lineage; IL12-mediated signaling events; Immune System; Immunoregulatory interactions between a Lym.

Citations


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References


Davis, MR; Zhu, ZW; et al. The role of IL-21 in immunity and cancer. CANCER LETTERS 358:107-114(2015).
Kaser, T; Mair, KH; et al. Natural and inducible Tregs in swine: Helios expression and functional properties. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 49:323-331(2015).

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