This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized.
Pathway
Drug metabolism - cytochrome P45, organism-specific biosystem; Drug metabolism - cytochrome P45, conserved biosystem; Glycolysis / Gluconeogenesis, organism-specific biosystem; Glycolysis / Gluconeogenesis, conserved biosystem; Histidine metabolism, organism-specific biosystem; Histidine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P45, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P45, conser.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Holmes, RS; Hempel, J; et al. Comparative studies of vertebrate aldehyde dehydrogenase 3: Sequences, structures, phylogeny and evolution. Evidence for a mammalian origin for the ALDH3A1 gene. CHEMICO-BIOLOGICAL INTERACTIONS 191:113-121(2011).
Zhang, RL; Miao, Q; et al. Genome-wide DNA methylation analysis in alcohol dependence. ADDICTION BIOLOGY 18:392-403(2013).
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COA
Certificate of Analysis
